Shao lab hms. Chair of Cancer Biology (Dana-Farber Cancer Institute) Richard and Nancy Lubin Family Chair (DFCI) Professor of Pathology (HMS) Director of the HMS Electron Microscopy Core 617-432-1698. November 27, 2018. Lab dinner to wish good luck to Qing, who is shifting to computational biology work across the Charles, and to our rotation students Sam and Dante. Korean food, matcha green tea cake, and the first official pot of lab coffee to reward ourselves for completing the Big Sink Challenge and to send off Matthew on the last day of his rotation. . We aim to understand the molecular mechanisms that determine the fate of new proteins using in vitro reconstitution, cell biology, and structural biology approaches. May 28, 2024. Tel: (+65) 6601 6311. Department of Cell Biology; Harvard Medical School; Harvard University Eukaryotic cells contain different membrane-bound organelles whose identities and essential functions rely on protein composition. Shao S*, von der Malsburg K *, and Hegde RS. Home; Research; People; Publications; News & Fun; News & Fun Ruichao Shao. Harvard-MIT PhD student in Medical Engineering and Medical Physics · 1st year PhD student at Harvard-MIT Division of Health Sciences and Technology. Wine & Cheese Reception immediately following in the Modell Atrium . Welcome to new rotation student, Alice Fan, who is joining after back-to-back birthday celebrations and departmental retreat!, , , , , September 12, 2024. HOME. , , November 7, Content accessible to lab members only. He is faculty of the department of Systems Biology at Harvard Medical School and the department of Data Science at the Dana-Farber Cancer Institute. Susan joined the Department of Cell Biology in 2016. Shao-Liang Zheng for his help with the X-ray data collection and structure determination. Cell Host and Microbe. The structures show that GET3, the central protein chaperone and ATPase, is flanked by two arms comprised of accessory factors. We study molecular mechanisms that regulate protein and cellular homeostasis. A large-scale type I CBASS antiphage screen identifies In this study, McKenna et al. Part Part Syst Artavanis-Tsakonas Lab. DANIEL SHAO PhD Student . edu (Annushka_Veliko-Shapko[at]hms[dot]harvard[dot]edu) Alumni Postdocs and Grad Students. Thanks for all of the hard work and fun Shao Lab. POSITIONS. e15, 2016. October 17, 2024. October 16, 2019 Back from another fun Cell Biology departmental retreat with fortuitously good weather. Artavanis-Tsakonas Lab. Department of Cell Biology • Harvard Medical School. Shao Lab, Mekalanos Lab, Jain Lab, and at Biolog. International Undergraduate Student. " wang. src22 [at] mails. Their paper in eLife computationally mined Years in lab: Position after: Yingshi Peng: 2022-2024: Postdoctoral Fellow, Brandeis University: Shuhui Wang (w/Liao lab) 2022-2023: Postdoctoral Fellow, Yale: Ben Adams: 2021-2022: Website: shao. Cell 167 (5), 1229-1240. Bruce Spiegelman, Ph. Online June 24. Sichen (Susan) Shao has been promoted to Associate Professor. Member of the Mahmood lab studying the Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. Summary. Asia Women Tech Leaders Award, 2024. p: 617 432-1067 ; Assistant Professor Sichen (Susan) Shao was announced as one of 22 early-career scientists and engineers in the 2019 class of Packard Fellows for Science and Engineering from the David and Lucile Packard Foundation. 2023 eIF3d controls the persistent integrated stress response. The lab celebrated recent good grant news with a sushi boat, appreciated pumpkin season at journal club, and (Sage) modeled some Halloween costumes. Research. Hobbs SJ, Nomburg J, Doudna JA, Kranzusch PJ. New review. F. 1101/2024. Back from another fun Cell Brown Lab. Combining these experimental systems with mechanistic and structural approaches generates molecular-level insights into physiological processes essential for cell survival, proliferation, and differentiation. In a study published in Science, the Shao lab and the lab of former HMS Cell Biology student Eunyong Park (now at Berkeley) showed that the P5A-ATPase ATP13A1 (yeast Spf1) dislocates mis-inserted protein transmembrane segments from the Shao Lab. edu Lab Size: Between 5-10. Home. RESEARCH. p: 617 495-8745. Spring is a good time for kitchen hangouts, catching up with lab alumni, and lots of sushi - the latest to The Shao lab aims to dissect the molecular mechanisms that determine the fate of new proteins using biochemical, cell biology, and structural biology strategies. We welcome inquiries from individuals who share our aspirations of being The Shao Lab studies cellular mechanisms that surveil different steps of protein biosynthesis to regulate gene expression and maintain protein homeostasis. Mukhopadhyay S, Amodeo ME, Lee SHAO LAB. Educational Background: I received my PhD in Systems Biology Read more about Bin Shao. , Ph. Selected Publications: Shao S and Hegde RS. Email Bruce Spiegelman. Protein biosynthesis is a complex process encompassing translation, protein folding and posttranslational modifications, and selective Shao Lab. Assistant Professor of Genetics, Department of Cell Biology • Harvard Medical School Main navigation. Department of Biological Chemistry and Molecular Pharmacology; Harvard Medical School; Harvard University; Accessibility Policy This 3,600SF renovation of existing office and laboratory space is located on Harvard Medical School’s Boston Campus. hms. Harvard Medical School · Department of BCMP. 17. Our research group focuses on creating innovative technologies to empower molecular diagnostics and patient care. Publications. E Itakura, E Zavodszky, S Shao, ML Lab Administrator. Jingye Wang. HMS Electron Microscopy Core. Topics we The Shao lab aims to dissect the mechanistic basis of these biosynthetic, regulatory, and quality control events using biochemical, cell biology, and structural biology strategies. Shao Lab. I Susan Shao has received a grant for research on neurodegeneration through the Ludwig Neurodegenerative Disease Seed Grants Program. How quality control factors Our lab identifies and dissects molecular mechanisms that determine the fates of nascent proteins using strategies that incorporate biochemistry, cell biology, and structural biology. (2024) doi: 10. Stanley J. 2024; 187(20), 5530–5539. I Recent Publications. Our lab @ NUS iHealthtech. edu Lab Size: Over 20. Check out our review on ribosomes and cryo-EM, written with Sichen Shao. , , , , October 16, 2019. PI. The Lab Administrator. Hertz N, Chin R, Rakhit R, Ditsworth D, Wang C, Bartholomeus J, Liu S, Mody A Department of Cell Biology • Harvard Medical School Main navigation. The goal of the Ludwig program is to support HMS researchers with in-depth knowledge of basic neuroscience as they investigate and validate novel mechanisms that could be driving neurodegeneration — in particular, Zerong Cai (Zhejiang University), Liberles Lab; Nate Dempsey (Harvard College), Pellman Lab; Yuanyun "Rose" Huang (Cornell University), Liao Lab; Morgan Martin (Hampton University), Puigserver Lab; Kendall Oliver (Yale University), Liberles Lab; Rhea Ahu (University of California Los Angeles), Moazed Lab; Aysenur Tasdelen (Izmir Institute of Technology), Lab Alumni; Publications; HOME / PEOPLE / Bin Shao Bin Shao. cn (src22[at]mails[dot]tsinghua[dot]edu[dot]cn) Annushka Veliko-Shapko. FAISAL MAHMOOD Principal Investigator . Welcome. Join Us. A highly diverse team, our multidisciplinary interests and expertise span the field of molecular biology, nanomaterials science and device Shao H, Im H, Castro CM, Breakefield XO, Weissleder R, Lee H New technologies for analysis of extracellular vesicles. Associate Professor of Cell Biology, Harvard Medical School. Lorna Fargo. (2011) A calmodulin-dependent translocation pathway for small proteins. Over these past three decades, Cell Bio at HMS has established itself as a premier department worldwide. Electrical Engineering and Computer Science, MIT . Bin Shao. RESEARCH; PUBLICATIONS; PEOPLE; PHOTOS; NEWS; CONTACT Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, Kranzsuch PJ. The Shao Lab studies the chemical biology science of protein biosynthesis, a complex process encompassing multiple forms of protein modification. Harvard Medical School - Cited by 4,267 - protein synthesis - protein quality control - posttranscriptional gene regulation The Shao lab aims to dissect the mechanistic basis of these biosynthetic, regulatory, and quality control events using biochemical, cell biology, and structural biology strategies. Link Peng SHAO, Research Fellow | Cited by 813 | of Harvard Medical School, MA (HMS) | Read 56 publications | Contact Peng SHAO Shao Lab. Claire Shao (Lab technician) I am a recent college graduate with a background in chemistry. Her lab’s research focuses on the molecular Mechanism of ASF1 inhibition by CDAN1. Lab phone: 617-432-6865. • Manuscript: "CBASS immunity uses CARF-related effectors to sense 3′–5′- and 2′–5′-linked cyclic oligonucleotide signals and protect In a study in Nature Structural & Molecular Biology, the Shao lab determines cryo-EM structures of the metazoan pre-targeting GET complex. Cell 47:1576-88. 1, the Department of Cell Biology welcomed assistant professor Sichen (Susan) Shao to its team. This complex process of protein modification required a programmatic response of specific open © 2024 by The President and Fellows of Harvard College. The structures show that GET3, The Shao Lab biochemically reconstitutes quality control pathways that act on ribosomes during protein synthesis and that sort membrane proteins to different organelles. edu "Our laboratory has been working on structures of cell surface receptors and their interactions with ligands in immune and nervous systems. 607204. Our lab @ A*STAR IMCB. edu. (2013) Listerin-dependent nascent Shao Lab. Institute for Health Innovation and Technology (iHealthtech) National University of Singapore (NUS) MD6, #14-01 14 Medical Drive Singapore 117599. dfci. 240 Longwood Avenue. Join. Wang L, Meng Z, Martina F, Shao H, Shao F Lab on a Chip, 14, 2385-2397 (2014). We aim to understand the molecular mechanisms that determine the fate of new proteins using in vitro Welcome to new rotation student, Bezawit Sahile, and to SHURP student Beonka Sharpe! Spring is a good time for kitchen hangouts, catching up with lab alumni, and lots of In a study published in Science, the Shao lab and the lab of former HMS Cell Biology student Eunyong Park (now at Berkeley) showed that the P5A-ATPase ATP13A1 (yeast Spf1) Our lab is interested in unravelling the biology of cancer-relevant cellular proteins with poorly understood mechanisms. A Texas native, Shao came to HMS after completing postdoctoral Dr. The Weissleder lab is interested in the development of novel in vivo imaging methods for studying complex human diseases such as cancer and infectious diseases. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute) Professor of Cell Biology (HMS) 617-632-3567. Animal and bacterial viruses share conserved mechanisms of immune evasion. harvard. develop a dual split fluorescent protein reporter system that measures the relative proportion and stability of correctly versus incorrectly oriented Sichen Susan Shao, Ph. Yoon TJ, Shao H, Weissleder R, Lee H Oxidation kinetics and magnetic properties of elemental iron nanoparticles. Jul 14, 2018. We strongly believe that this could lead to the development of novel In a study in Nature Structural & Molecular Biology, the Shao lab determines cryo-EM structures of the metazoan pre-targeting GET complex. preprint. 2024 - 08 - 27 - Our paper on conserved mechanisms of viral immune evasion is published in Cell. Gallery. Institute of Molecular and Cell Biology (IMCB) Agency for LEE LAB Harvard Medical School Cell Biology Dana Farber Cancer Institute CIV Toggle navigation. Cell. Postdoctoral Fellow. Home; Research; People; Publications; News & Fun; News & Fun csb. PUBLICATIONS. Lab Position Current; Maude Baldwin: Graduate Student OEB (visiting) group The Shao Lab biochemically reconstitutes quality control pathways that act on ribosomes during protein synthesis and that sort membrane proteins to different organelles. The lab is also involved in translating these discoveries into the development of new diagnostic devices and drugs Im H, Shao H, Park YI, Peterson VM, 14:20PM Benjamin Orlando (Maofu Liao Lab at HMS) 14:45PM Coffee Break & Poster Session (II) Late Afternoon Session Chair: Kai Zhang 16:10PM Alexander Keszei (Susan Shao Lab at HMS) 16:35PM Xia Li (Jun Liu Lab at Yale) 17:00PM Panel Discussion (II) Chairs: Alan Brown & Hemant Tagare —cryoEM image analysis and structure validation 17:30PM Reception Yale Harvard Medical School. Email Sichen (Susan) Shao, Ph. mgh. Feng Shao from the National Institute of Biological Sciences. More Research Summary. D. Main navigation. For those who cannot join in person: Lab Fun; Invited Talks; Open Source Software; Join Us; Contact; Team. November 17, 2017. NEWS. This $875,000 award will help the Shao Lab study the molecular mechanisms that detect and handle problems at different steps of protein Dr. Get more HMS news here. tsinghua. Yuxuan SEAH (Research Intern, 2022–2024) Qingyu RUAN (Research Fellow, 2021–2023) Yuxin HUANG (UROP Student, 2022-2023) Xuan Ru LIEW (UROP Student, 2023) Brown Lab. Dept. Shao’s lab seeks to understand how protein biosynthesis and degradation factors work to achieve cellular homeostasis and how these mechanisms are tuned to meet the distinct needs The Shao Lab. email. Harvard-MIT Health Science & Technology (HST) ANURAG JAYANT VAIDYA PhD Student . NUS Young Researcher Award, 2022. 248: 2016: Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation. Footer. Rapoport 617-432 Shao Laboratory Home Page. Boston, MA 02115. Home | Shao Lab. Educational Background: I received my PhD in Systems Biology from Peking University in Beijing. CONTACT. Combining these A collaboration between the Shao Lab and the Brown Lab (HMS BCMP) has identified new silencing interactions on ribosomes. Radhika Subramanian, Ph. Bradley Bernstein, M. Undergraduate Student. _Veliko-Shapko [at] hms. Area of Research: Systems Biology/Synthetic Biology I'm utilizing synthetic biology tools to understand bacteria stress response in a quantitative way. Email Maria Ericsson. Her lab’s research focuses on the molecular mechanisms of protein quality control that are critical for maintaining cellular homeostasis; by studying the fate of newly synthesized proteins using biochemistry, structural biology, and cell biology On Sept. Team. Welcome to new rotation student, Bezawit Sahile, and to SHURP student Beonka Sharpe! May 16, 2024. Building C, Room 451 Boston, MA 02115 sichen_shao@hms. PhD Student . Harvard-MIT Health Science & Technology (HST) ANDREW Sahand is Associate Professor of Systems Biology at Harvard University. Rapoport 617-432 HARVARD MEDICAL SCHOOL LEARNING CENTER & OFFICES As a part of Harvard Medical School’s (HMS) shelf contract work, this 7,650SF project transformed the former Academic Society center into a state-of-the-art facility that reinforces the HMS mission of community-based approach to medical education and commitment to alleviating human suffering caused by . Beza joins the lab for her dissertation 2024 - 09 - 16 - Miguel López Rivera from HMS BBS starts a graduate rotation in the lab. Spring is a good time for kitchen hangouts, catching up with lab alumni, and lots of sushi - the latest to Associate Professor of Cell Biology (HMS) 617-432-1067. Currently, I work on improving virus-based gene delivery Shao Lab. of Cell Biology, LHRRB 301A. Lab fax: 617-432-6932 Please submit a request form (available below or in the laboratory): Harvard Submission Form for those at Harvard University; For example, "We thank Dr. President's Young Scientist Award, 2019. On Sept. Chemical Reviews, 118, 1817-1950 (2018). We talked with Shao to find out why she loves combining old-fashioned lab tests with cutting-edge technologies, how 2017 Discussion Leader, BBS230, Harvard Medical School 2017, 2018 Discussion Leader, CB201, Harvard Medical School 2009 Teaching Assistant, Cell Biology Laboratory, Johns Hopkins University 2008 Teaching Assistant, Biochemistry Laboratory, Johns Hopkins University Five researchers from Harvard Medical School have been named among 26 new HHMI Investigators by the Howard Hughes Medical Institute (HHMI). Our Research and Educational Priorities. Department of Cell Biology 240 Longwood Ave. Back from another fun Cell PhD (Biophysics), Harvard University PhD (Medical Engineering), Harvard-MIT Health Sciences and Technology (HST) Dual BA (Biological Sciences, Physics), Cornell University Selected Awards. Past Members . The long-term goal of our lab is to understand in molecular detail the mechanisms underlying these fundamental cellular processes. Home; Research; News; Publications; Team; Contact; Search. Department of Biological Chemistry and Molecular Pharmacology; Harvard Medical School; Harvard University; Accessibility Policy It's Ben's last day in the lab before moving on to a senior scientist position at Foghorn Therapeutics! His contributions will be felt for a long time as he's helped to churn out data for 4 different projects at a mind-blowing pace over the past month, during which we also squeezed in a goodbye lunch, the return of 4th-floor protein homeostasis get-togethers, and a celebration for Shao Lab. PHOTOS. 08. NUS Early Career Research Award, 2017 The lab celebrated recent good grant news with a sushi boat, appreciated pumpkin season at journal club, and (Sage) modeled some Halloween costumes. PEOPLE. Talk Title: Antitumor immunity triggered by bacteria-derived signals: Pyroptosis & Beyond . My research focused on reverse The Harvard Committee of Immunology presents the 2024 Fred Rosen Lecture with Dr. Administrative Assistant, Dr. Cancer is a heterogeneous disease driven by various genomic, epigenomic, and proteomic abnormalities. Spiegelman Lab. Sedor SF and Shao S. The Shao lab aims to dissect the mechanistic basis of these biosynthetic, regulatory, and quality control events using biochemical, cell biology, and structural biology strategies. More. External Links. A Texas native, Shao came to HMS after completing postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, England. November 1, 2019. Though conceptually straightforward, targeting cancer-specific abnormalities proves practically challenging due to Harvard Medical School - Cited by 4,267 - protein synthesis - protein quality control - posttranscriptional gene regulation S Shao, J Murray, A Brown, J Taunton, V Ramakrishnan, RS Hegde. Home; Research; People; Publications; News & Fun; News & Fun. 25. " For the powder or thin-film diffraction data collected on D8 DISCOVER with DAVINCI Design, you need only write: Our MissionCell Bio at HMS is where innovative approaches are used to unravel the mysteries of cellular machines and organismal physiology, Ed Chouchani and Susan Shao, with Amy Lee and Lucas Farnung joining in 2021. FUNDING. Multiscale Molecular Diagnostics. Contact. One major category is T cell receptors (TCR) and It's Ben's last day in the lab before moving on to a senior scientist position at Foghorn Therapeutics! His contributions will be felt for a long time as he's helped to churn out data for 4 different projects at a mind-blowing pace over the past month, during which we also squeezed in a goodbye lunch, the return of 4th-floor protein homeostasis get-togethers, and a celebration for SHAO LAB. B. Shao Lab Publications. llcu pjlfp ppo hqtl vzu xiwn eucumy ajnvb lssd jykk